amyloid precursor protein — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP1655	β-Amyloid Protein Precursor 770 (135-155)	β-Amyloid Protein Precursor 770 135-155
	Beta-Amyloid Protein Precursor 770 (135-155)Aβ Protein Precursor 770 (135-155)
T6483	EHT 1864	EHT 1864 2HCl	Rho , Ras
	EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).		Rho , Ras
T9713	δ-secretase inhibitor 11		Beta Amyloid , Caspase
	δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.		Beta Amyloid , Caspase
T80695	β-Amyloid precursor protein (96-110), cyclized (human)
	β-Amyloid precursor protein (96-110), cyclized (human), a segment of the amyloid precursor protein, serves as a research tool in Alzheimer’s disease studies [1].
T7490	ARN2966		Beta Amyloid
	ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.		Beta Amyloid
T14673	BMS 299897		Beta Amyloid , Gamma-secretase
	BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).		Beta Amyloid , Gamma-secretase
T11178L	ELN318463 racemate	ELN318463 (racemate),ELN 318463 racemate	Gamma-secretase
	ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.		Gamma-secretase
T14338	Atabecestat	JNJ-54861911	BACE
	Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a ...		BACE
T61439	DSS30		Beta Amyloid , BACE , CDK
	DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).DSS30 can be used for the prevention and tr...		Beta Amyloid , BACE , CDK
T4364	Aftin-4	Aftin 4,Aftin4	Beta Amyloid , Gamma-secretase
	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus...		Beta Amyloid , Gamma-secretase
T80622	Trontinemab
	Trontinemab, a bispecific humanized IgG1-κ antibody, targets the amyloid beta A4 precursor protein (APP) and transferrin receptor p90, CD71 (TFRC). It is utilized in research on Alzheimer's disease (AD) [1] [2].
T3161L	BACE-IN-1 acetate	BACE-IN-1 acetate (350228-37-4，Free base)	BACE
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precursor protein (APP) c...		BACE
TN2190	Scoulerine		Apoptosis , Beta-Secretase , BACE , Parasite
	Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.		Apoptosis , Beta-Secretase , BACE , Parasite
T13253	Umibecestat	CNP520	BACE
	Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of al...		BACE
T27944	LY3202626	LY 3202626,LY-3202626
	LY3202626, an amyloid precursor protein secretase (BACE protein) inhibitor, is used for the treatment of Alzheimer's disease.
T3161	β-Secretase inhibitor-STA		Beta-Secretase
	BACE-IN-1 is amyloid precursor protein beta-secretase inhibitor		Beta-Secretase
TP1303	β-Amyloid (1-40)	β-Amyloid 1-40
	Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases.
T14525	Begacestat	GSI-953	Beta Amyloid
	Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's disease.		Beta Amyloid
T12429	PF-06751979		BACE
	PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).		BACE
T70366	PF-06663195
	PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1).